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Ask your health care provider if Colchicine/Probenecid may interact with other medicines that you take. Colchicine therapy must be started before nephrotic syndrome or uremia develops; initiation of treatment after either of these conditions is present will not prevent further deterioration of renal function {11} {13}. However, the high risk of toxicity associated with intravenous administration of colchicine must be considered {04} {09}. Colchicine inhibits secretion of serum amyloid A in patients with familial Mediterranean fever {04}. Colchicine may provide additional benefit when used concurrently with ursodiol for this indication {30}.
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