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The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. Unlike PURINETHOL (mercaptopurine) and IMURAN® (azathioprine), Thioguanine may be continued in the usual dosage when allopurinol is used conjointly to inhibit uric acid formation. A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. Keep Allopurinol out of the reach of children and away from pets. Do not use this medication if you are allergic to didanosine, or if you are also taking allopurinol (Zyloprim) or ribavirin (Rebetol, Ribasphere, Copegus Virazole). It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
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