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Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA. 25 percent increase in percent atheroma volume (PAV) in those taking rimonabant, compared to 0. Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. Food and Drug Administration panel recommended that rimonabant should not be given the FDA's blessing because of continuing concerns about increased risks for suicidal thoughts among some users. A CB1 antagonist called rimonabant is currently marketed overseas for weight loss.

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